CAPACITÉS’ teams in monitoring host immune response, preclinical assays and viral vector production offer a complete range of support for the development of drug candidates.
With internationally recognized know-how in the field of gene therapy, our experts offer the responsiveness of a CRO (Contract Research Organization) in the discovery and development phases of gene therapy products.
Summary
Services
Proof of concept
Preclinical data
Manufacturing
Preclinical assays
Technology platforms
In close collaboration with TaRGeT UMR 1089 gene therapy laboratory (UMR INSERM-Nantes Université), we propose the development of processes for the production and characterization of viral gene transfer vectors derived from adenoviruses and AAV. These vectors are intended for applications ranging from basic research to preclinical trials.
In a nutshell
AAV vectors
vector plasmids
analysis processes
R&D
The research teams and the vector production center of TaRGeT UMR 1089 Gene therapy laboratory work together to ensure reliable, high-quality production and characterization of viral vectors. They can also develop custom analytical tests and new innovative characterization tests.
In a nutshell
Upstream technologies
Downstream technologies
Experts in the monitoring of host immunity in gene therapy protocols, we provide analyses for monitoring immune responses directed against the vector and against the transgene product. We assist in the development of your gene therapy products, from the research project to toxicology studies and clinical trials.
In a nutshell
Humoral immunity
Cellular immunity
Sample preparation
Analyses for monitoring the immune response against the vector or the transgene product are carried out by the GTI (Gene Therapy Immunology Core) platform of TaRGeT UMR 1089 Gene therapy laboratory. This platform has complete technical means for the Immune monitoring of gene therapy studies.
In a nutshell
ELISpot
Cell proliferation test
Tetramer
flow cytometry
Cellular neutralization test
ELISA
Western Blot
Luminex
Plate washer
Multimode microplate reader
ELISpot reader
Turbo gel transfer system
Evaluation of the biodistribution and expression profile of transgenes is necessary to understand the pharmacology and pharmacokinetics of a therapeutic product. We are recognized as experts in the molecular and biochemical analyses required to assess the efficacy and biosafety of gene therapy products.
In a nutshell
Evaluation of functionality
Evaluation of biodistribution
Expression Profile Assessment
development of preclinical studies
Absolute quantification
Our leading expertise, in the evaluation of biodistribution and expression profiles of transgenes, is implemented using multiple tools and equipment available on PAC (Preclinical Analytics Core) platform of the Nantes UMR1089 gene therapy laboratory.
In a nutshell
Tissue shredder
Pipetting machine
Nanophotometer
microplate reader
Colorimetric and fluorimetric reader
Electrochemiluminescence reader
PCR and qPCR instruments
Turbo gel transfer system
Our gene therapy experts carry out their engineering work directly in the research laboratories of Nantes Université, particularly in TaRGeT UMR 1089 Gene therapy laboratory
On a daily basis, they combine technical resources and scientific discoveries to meet your R&D challenges.
Capacités teams inspire, harness and couple numerous cutting-edge skills covering a wide range of applications and expertise to meet all of your innovation needs with passion and commitment!
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