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Preclinical trials for drug development and drug candidate validation

Life science

Our experts lead preclinical testing and support pharmaceutical and biotechnology companies in the drug discovery and drug development phases: pharmacology, pharmacokinetics and toxicology studies.

Save time in the experimentation phase. We develop the preclinical studies for the validation of drug candidates and food compounds, evaluate the therapeutic or protective effects of molecules of interest and characterize the functional effects of a pharmaceutical product (action, target organ, active dose).

Associated with the facility core for function exploration Therassay (certified ISO9001: 2015), we operate as a CRO (contract research organization). WE offer a simplified service covering a wide range of functions: neuromuscular, metabolic, vascular, cardiac, pulmonary, digestive, oncology-haematology; as well as consulting services, study design and preclinical trials.

Summary

Services

Benchmarck and consulting

Study design

Preclinical assays

Assessments: Analyses, Recommendations

Support: development, certification…

Preclinical research and assays on muscle function

Physiopathological analyses, muscle fatigue studies and muscle tone measurements are conducted by our experts to study muscle pathologies such as sarcopenia and muscle atrophy.

Different methods and a high level of expertise are offered to answer specific questions related to the evaluation of muscular strength, the analysis of gain or loss of muscular strength and the improvement of cognitive functions or stress and anxiety states.

In a nutshell

evaluation of muscular strength

analysis of gain or loss of muscular strength

improvement of cognitive functions

stress and anxiety states

Assessment of general behavior and analysis of global motor and muscle function

Effectiveness laboratory testing of pharmaceutical products and food supplements on neuromuscular function: strength, muscle fatigue, endurance

Measurement of limb muscle strength
Measurement locomotion and curiosity activities
Measurement of endurance and resistance to effort
Exploration of motor coordination
Training, muscle fatigue and exercise resistance assessment
Semi-automated system for gait exploration and qualitative/quantitative analysis of locomotion
Exploration of neuromotor function and muscle function

Measurement of muscle contractions at the organ, muscle cells and calcium homeostasis levels

Evaluate the efficacy of food supplements or drug candidates: compare a reference product with products on the market (plant extracts, soluble milk proteins, muscle relaxants, etc.)

Pharmacological approach: drug trials, plant extracts, etc.

Neuromuscular evaluation: anxiety, depression

Preclinical trials for the functional exploration of the muscular system associated with cognitive functions.

Preclinical evaluation and validation of drug candidates in onco-hematology

This unique expertise is offered to biotechs, pharmaceutical companies and research institutions to evaluate the clinical potential of drug candidates for hematological malignancies : lymphomas, myelodysplastic syndromes, hematological malignancies, etc.

In a nutshell

In vitro study

cell lines

clinical potential of drug candidates

hematological malignancies

Evaluation of the therapeutic potential of compounds on MM (Multiple Myeloma) and MCL (Mantle Cell Lymphoma) cell lines
Dissection of cellular mechanisms induced by compounds
Identification of the best combination with approved drugs
Cell lines characterization
In vitro assays available as standard – others upon request

Drug efficacy evaluation using a panel of MM (Multiple Myeloma) xenograft models, recapitulating MM heterogeneity in immunodeficient subjects (tumor volume monitoring)
Models development for hematological cancers
Monitoring, endpoints and characterization of drug efficacy
Measurement of tumor volume

Monitoring of clinical parameters (health status, behavioral monitoring, treatment response, weight change…)
Samples for further study: e.g. serum, blood, tumor tissue
Tumor tissue analysis: e.g. Western blot, qPCR
Exploration in hematological malignancies

Engineering at Capacités

Therassay is a core facility functional exploration for cardiovascular, metabolic, neuromuscular, digestive, respiratory and cancerous pathologies

Challenges we’ve met

Capacités’ study shows that a valerian extract relaxes muscles

A preclinical study to assess whether a specific valerian root extract can affect muscle function

A Milk Ingredient’s Scientifically Confirmed Benefits

A Pre-Clinical Study on a Milk Protein’s Functional Benefits

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Capacités teams inspire, harness and couple numerous cutting-edge skills covering a wide range of applications and expertise to meet all of your innovation needs with passion and commitment!

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