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Cyclodextrins for Microencapsulation

Cyclodextrins have an inclusion capacity that enables many hydrophobic compositions to become soluble in an aqueous solution.

There are many uses for this molecular tool, such as controlling the release of scents and flavors, improving the bioavailability of a therapeutic compound, capturing pesticides, encapsulating toxic organic compounds present in water, etc.

Our engineering and R&D services

Our experts work with you on your research and development projects. They help you develop formulation strategies, optimize inclusion complexes, improve compound solubility, ensure stability in volatile molecules, and assist in many other research problems.

Improving inclusion properties

Optimizing the stability, solubility, and bioavailability of active and inactive ingredients in medicine

  • Selective functionalization of cyclodextrins
  • Chemical modification of commercial cyclodextrins
  • Monofunctionalization of cyclodextrins
  • Synthesis of anionic, cationic, and amphiphilic cyclodextrins

Complexation studies

Characterizing inclusion and complexation properties to make a composition’s hydrophobic molecules water soluble

  • Preparing inclusion complexes
  • Encapsulating molecules of biological interest / active ingredients, inactive ingredients, food products, and peptides
  • Kneading method, lyophilization, co-precipitation, and microwave
  • Powdered composition for reconstitution
  • Characterizing association constants

Determining cyclodextrin-ligand affinity constants

Measuring the molecular binding affinity between a ligand and its target via Nuclear Magnetic Resonance (NMR).

  • Titration by NMR-1H
  • Assay by UV
  • Determining the stoichiometry of complexes
  • Higuchi method

Aqueous solubility study by phase diagram

Measuring the solubility of an active or hydrophobic ingredient before and after cyclodextrin complexation.

  • Implementing appropriate protocols
  • Determining types of phase solubility diagrams (AP, AL, AN, BS)
  • Solubility of complexes formed in an aqueous solution
  • Controlled release kinetics in various conditions (pH, temperature)

Encapsulated molecule stability study

Using cyclodextrins to protect the content of an active substance over time and to prevent the appearance of degradation products

  • Thermal and photochemical degradation
  • Degradation kinetics using HPLC, RMN
  • Thermal analysis: TGA, DTG

Mastering sustained release: antagonist cyclodextrins

Encapsulating and binding molecules to reduce active ingredients’ effects in a target environment.

  • Designing cyclodextrins for decorporation
  • Decontaminating water and soil
  • Trapping active ingredients and scents
  • Using cyclodextrins for formulating cosmetic products or medicines (muscle relaxants, therapeutic compounds that can selectively attract and capture E.coli-type bacterial strains and halt their adhesion, e.g., for treating Crohn’s disease)
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