Enhancing the efficacy, stability, and specificity of molecules through glycoscience
Are you looking to solubilize a hydrophobic active ingredient, develop targeted therapies (AAV), design effective vaccines, or create bio-guided cosmetic ingredients?
To address these challenges, CAPACITÉS transforms the complexity of sugars into concrete R&D solutions for the pharmaceutical, cosmetics, and nutrition industries.
Summary
Services
No matter what challenges you face, our experts provide you with practical and innovative solutions.
Glycochemistry and molecular targeting
Although your active ingredients show promise, they often lack specificity or cause adverse effects.
The attachment of targeted sugar moieties (site-selective glycoconjugation) transforms your molecules into “guided missiles” recognized by specific cellular receptors (lectins).
- Increased therapeutic index and reduced toxicity.
- Modification of the surface of viral capsids (AAV) and antibodies (ADC).
- Development of glycoconjugate vaccines that elicit a strong immune response.
In a nutshell
Synthesis of Glycosides
Bioconjugation
Development of glycoconjugates
Measurement of glycomolecules
More
Synthesis of glycosides
- Orthogonal Protections/Deprotections
- Selective functionalizations
- O, S, C, N-Glycosides
- Cyclodextrin chemistry
- Multivalence/Polymers
- Glycosidase inhibitors/Activators
- Glyco-nanoparticules
Development of glycoconjugates
- Lys, Tyr, and Cys functionalization via bioconjugation
- Electrochemical functionalization
- Affinity-guided bioconjugations
- Site-Selective Conjugation (directed mutagenesis, incorporation of non-natural amino acids, metabolic functionalization)
Quantification of glycomolecules
- Analysis of Reaction Mixtures
- Capillary Electrophoresis
- HPAEC-PAD…
Solubility and stability of active ingredients
In fact, many active ingredients remain difficult to utilize due to their insolubility in water or their instability.
Therefore, we use commercially available, chemically modified cyclodextrins to encapsulate and protect the target molecule.
- A 10- to 100-fold increase in bioavailability and water solubility.
- Prolonged, time-controlled release (slow-release).
- Protection against oxidation and masking of odors and bitterness.
In a nutshell
Inclusion
Complexation
Solubility
Stability
Extended-release
Our expertise in sugar chemistry
- Organic Synthesis: Custom synthesis of complex carbohydrate molecules, from proof of concept to pilot-scale production.
- Bioconjugation and targeting: Covalent and site-specific grafting of glycan motifs onto proteins, peptides, antibodies, and nanoparticles.
- Vectorization and Formulation: Design and modification of custom cyclodextrins for the microencapsulation of active ingredients (cyclodextrin encapsulation, improved bioavailability, active ingredient, solubilization of hydrophobic molecules).
- Interactions and screening: Detailed analytical characterization, quantification of glycomolecules, and validation of inhibition on biological targets (measurement of sugar-protein affinity, lectin inhibition assay, glycan-receptor interactions, HPAEC-PAD quantification)
In a nutshell
Synthesis
Bioconjugation
Vectorization
screening
Engineering at CAPACITÉS
Nantes chemistry laboratory
On the one hand, CEISAM focuses primarily on three research areas: the synthesis of organic molecules and hybrid materials, methodological developments in analytical chemistry, and molecular modeling.
Our technical ressources
We have access to more than 150 pieces of equipment in the University of Nantes’ laboratories.
Need an innovative and resourceful partner?
Capacités teams inspire, harness and couple numerous cutting-edge skills covering a wide range of applications and expertise to meet all of your innovation needs with passion and commitment!
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