Significantly increasing the solubility of active ingredients via cyclodextrins encapsulation

Cyclodextrins are a cyclic oligosaccharide derived from amylose. These molecules, featuring a hydrophobic cavity and a hydrophilic surface, serves to resolve two issues which are frequently encountered in the development of medicinal products and active ingredients in general: the solubility and stabilisation of the molecules in question. There are obvious benefits to be gained from using cyclodextrins, providing that this is backed by specialised skills in glycoscience in order to optimise its affinity with the relevant compound.

We asked two of Capacités experts to explain this concept in more depth: Dr Sébastien Gouin, CNRS from the CEISAM Laboratory, and Dr Dimitri Alvarez-Dorta, an R&D engineer specialised in organic chemistry.

Dr Sébastien Gouin and Dr Dimitri Alvarez-Dorta, specialised in organic chemistry.

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